A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder

Aim: Bipolar disorder is a multifactorial being linked with dysregulation of several genes. Among the recently acknowledged factors in pathophysiology bipolar are non-coding RNAs (ncRNAs). Methods: We searched PubMed and Google Scholar databases to find studies that assessed expression profile miRNAs, lncRNAs circRNAs disorder. Results: Dysregulated ncRNAs patients have been enriched neuron-related pathways such as GABAergic glutamatergic synapses, morphine addiction pathway redox modulation. Conclusion: Altered these transcripts provides clues for identification pathogenesis this design targeted therapies treatment patients.